Synthesizes Azo derivatives linked 1,2,3-triazols ring and studying their biological activity

Abstract

In this  research we studied the synthesis of  Azo derivatives which linked 1,2,3-triazols ring and studying the biological activity of this derivatives. We  use a primary amine which is N,N-diaminodiphenylmethan  as an initiator for the reaction this amine reacted with NaNO₂ \HCl  than with 1-methyl-¹H-1,2,3-triazole-4-carbaldehyde in presence NaOH to produce compound (1) , after that the (1) compound reacted with p-aminoacetophenone  using ethanol as solvent and NaOH as catalyst to give chalcone (2), which is reacted with urea, phenyl hydrazine, hydrazine hydrate  to produce thiazine derivative (3), pyrazole derivative (4) and pyrimidine derivative (5)   respectfully. Compounds characterization was achieved by FT-IR,¹³C-NMR and ¹H-NMR then we studied their biological  activity which was founded that all prepared Compounds have good activity